Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Cell Host Microbe. 2010 Jan 21;7(1):1-2. doi: 10.1016/j.chom.2009.12.006.
Tir, a translocated effector protein from enteropathogenic E. coli (EPEC), contains two phosphotyrosines that initiate cellular signaling cascades, leading to localized actin polymerization into pedestals. A recent study now shows that two additional tyrosines within Tir recruit the inositol phosphatase SHIP2 to generate a PI(3,4)P2-enriched membrane platform that stabilizes pedestal assembly.
Tir 是肠致病性大肠杆菌（EPEC）的一种易位效应蛋白，含有两个磷酸酪氨酸，可启动细胞信号级联反应，导致局部肌动蛋白聚合形成基脚。最近的一项研究表明，Tir 内的另外两个酪氨酸招募肌醇磷酸酶 SHIP2，产生富含 PI(3,4)P2 的膜平台，稳定基脚组装。
