白细胞介素-13 在委内瑞拉旋毛虫感染大鼠模型中的作用。
Role of IL-13 in a model of Strongyloides venezuelensis infection in rats.
机构信息
Department of Bioquímica e Immunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Avenida Antonio Carlos 6627, Campus Pampulha, Belo Horizonte, MG 31270-901, Brazil.
出版信息
Microbes Infect. 2010 May;12(5):409-14. doi: 10.1016/j.micinf.2010.01.012. Epub 2010 Jan 29.
IL-13 is a cytokine known to play a role in several pulmonary diseases, including asthma and fibrosis. The role of IL-13 in the context of pulmonary changes induced by helminth infection is unclear. Rats experimentally infected with Strongyloides venezuelensis and treated with anti-IL-13 neutralizing antibody were used to evaluate the role of IL-13 on functional and inflammatory changes of host lungs, and on parasite control. S. venezuelensis-induced airway hyperreactivity was IL-13-independent, but IL-13 played an essential role in driving airway mucus production and eosinophil infiltration. IL-13 was important for the control of egg production but not establishment in the intestine.
白细胞介素 13（IL-13）是一种细胞因子，已知其在多种肺部疾病中发挥作用，包括哮喘和纤维化。IL-13 在寄生虫感染引起的肺部变化中的作用尚不清楚。本研究使用委内瑞拉刚地弓形虫感染的大鼠和抗白细胞介素 13 中和抗体治疗来评估 IL-13 对宿主肺部功能和炎症变化以及寄生虫控制的作用。委内瑞拉刚地弓形虫感染引起的气道高反应性与白细胞介素 13 无关，但白细胞介素 13 在驱动气道粘液产生和嗜酸性粒细胞浸润方面起着至关重要的作用。白细胞介素 13 对控制卵的产生很重要，但对肠道中的定植没有影响。
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