间隙关节成形术后颞下颌关节强直的术后放疗效果：一项使用绵羊的动物研究
Effects of postoperative radiotherapy for temporomandibular joint ankylosis after gap arthroplasty: an animal study using sheep.
作者信息
Takaishi Makoto, Kurita Kenichi, Hatano Yuko, Matsuura Hiroaki, Borg Martin, Goss N Alastair
机构信息
First Department of Oral and Maxillofacial Surgery, Aichi Gakuin University School of Dentistry, Nagoya, Aichi, Japan.
出版信息
J Oral Maxillofac Surg. 2010 Aug;68(8):1763-9. doi: 10.1016/j.joms.2009.09.009. Epub 2010 Feb 1.
PURPOSE
The aim of the present study was to examine the effects of postoperative irradiation on reducing heterotopic bone formation after gap arthroplasty release of temporomandibular joint ankylosis.
MATERIALS AND METHODS
Five sheep underwent induction of right temporomandibular joint ankylosis. After 3 months, the ankylosis was released by gap arthroplasty. At 24 hours after the release, they received a single radiation dose of 10 Gy. All sheep were sacrificed at 3 months after gap arthroplasty release. The body weight, jaw opening amount, and radiographs were measured at key intervals, with histologic assessment after death. The findings were compared with those in a control group treated with gap arthroplasty without irradiation.
RESULTS
The clinical measurements, radiographs, and histologic findings all revealed less evidence of reankylosis in the irradiated sheep.
CONCLUSION
The results of the present study have shown that a single radiation dose at 24 hours after gap arthroplasty for temporomandibular joint ankylosis inhibits heterotopic ossification.
目的
本研究旨在探讨术后放疗对减少颞下颌关节强直间隙关节成形术后异位骨形成的影响。
材料与方法
五只绵羊接受右侧颞下颌关节强直诱导。3个月后，通过间隙关节成形术松解强直。松解术后24小时，它们接受了10 Gy的单次辐射剂量。所有绵羊在间隙关节成形术松解后3个月处死。在关键时间间隔测量体重、张口度和X线片，并在死后进行组织学评估。将结果与未接受放疗的间隙关节成形术治疗的对照组进行比较。
结果
临床测量、X线片和组织学检查结果均显示，接受放疗的绵羊再强直的证据较少。
结论
本研究结果表明，颞下颌关节强直间隙关节成形术后24小时的单次辐射剂量可抑制异位骨化。
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