Department of Chemistry, Xinzhou Teachers University, Xinzhou 034000, China.
Ultrason Sonochem. 2010 Apr;17(4):685-9. doi: 10.1016/j.ultsonch.2009.12.019. Epub 2010 Jan 4.
A mild and efficient method has been developed using ultrasound irradiation for the synthesis of imidazolium and pyridinium salts based on the Zincke reaction. Tertiary nitrogen nucleophiles such as pyridines and imidazoles can be alkylated with primary amine by simply using their ammonium form Zincke salts. In almost all cases, a clear yield increase results and a dramatic reduction of the reaction time accompanied by an improved quality of the products occurs.
一种温和高效的方法已经被开发出来,使用超声辐射来合成基于 Zincke 反应的咪唑𬭩盐和吡啶𬭩盐。通过简单地使用它们的铵形式的 Zincke 盐,叔氮亲核试剂如吡啶和咪唑可以与伯胺烷基化。在几乎所有情况下,都会得到明显的产率提高,反应时间显著缩短,并且产物的质量得到改善。