Erdem Guliz, Salazar Raymond, Kimata Chieko, Simasathien Thitiwan, Len Kyra A, Bergert Lora, Melish Marian
Department of Pediatrics, University of Hawaii, Honolulu, HI 96826, USA.
Clin Pediatr (Phila). 2010 May;49(5):477-84. doi: 10.1177/0009922809352805. Epub 2010 Jan 28.
The clinical and laboratory findings and outcomes of methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) Staphylococcus aureus osteomyelitis have not been studied in Hawaii.
Retrospective inpatient chart reviews of 62 culture-proven osteomyelitis patients between 1996 and 2007 were performed.
Fifteen patients (24%) had MRSA infection, and 47 patients (76%) had MSSA infection. Length of stay, chronic health problems, total duration of fever, and length of treatment were not significantly different between MRSA- and MSSA-infected patients. The peak erythrocyte sedimentation rate and C-reactive protein values were higher among MRSA infected patients (P values: .009 and .003, respectively).The systemic complication rate was higher in MRSA-infected patients (P value: .018).
Differing from other pediatric staphylococcal infections in Hawaii, the majority of the patients had MSSA infection. Pacific Islander and Native Hawaiian ethnicities were affected disproportionately and had MRSA infection more frequently. MRSA-infected patients had frequent surgical procedures and systemic complications.
夏威夷尚未对耐甲氧西林金黄色葡萄球菌（MRSA）和甲氧西林敏感金黄色葡萄球菌（MSSA）引起的骨髓炎的临床、实验室检查结果及预后进行研究。
对1996年至2007年间62例经培养证实为骨髓炎患者的住院病历进行回顾性分析。
15例患者（24%）感染MRSA，47例患者（76%）感染MSSA。MRSA感染患者和MSSA感染患者在住院时间、慢性健康问题、发热总时长及治疗时长方面无显著差异。MRSA感染患者的红细胞沉降率峰值和C反应蛋白值更高（P值分别为0.009和0.003）。MRSA感染患者的全身并发症发生率更高（P值：0.018）。
与夏威夷其他儿童葡萄球菌感染不同，大多数患者感染的是MSSA。太平洋岛民和夏威夷原住民受影响比例过高，且MRSA感染更为频繁。MRSA感染患者常需进行外科手术且易出现全身并发症。
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