Ogawa Sumito
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo.
Clin Calcium. 2010 Feb;20(2):251-7.
During aging process in men, decline of androgen level is involved in symptoms of hypogonadism, and recent findings suggest that sex hormones are crucial for skeletal development and maintenance of bone mineral properties. In practice, androgen replacement therapy has not been established for bone-related symptoms in late onset hypogonadisim or male osteoporosis. Whereas recent evidences suggest that bone mineral properties are improved by androgen replacement therapy in aging male, further studies including large clinical trials are necessary to assess long-term benefits and risks by the therapy.
在男性衰老过程中，雄激素水平下降与性腺功能减退症状有关，最近的研究结果表明性激素对骨骼发育和骨矿物质特性的维持至关重要。实际上，对于迟发性性腺功能减退或男性骨质疏松症的骨骼相关症状，尚未确立雄激素替代疗法。然而，最近的证据表明，雄激素替代疗法可改善老年男性的骨矿物质特性，需要进一步开展包括大型临床试验在内的研究，以评估该疗法的长期益处和风险。
