Saito Makoto, Mori Akio, Irie Tatsuro, Tanaka Masanori, Morioka Masanobu, Ozasa Mariko, Kobayashi Takahiko, Saga Akiyoshi, Miwa Kimiaki, Tanaka Shinya
Department of Internal Medicine, Aiiku Hospital, Sapporo.
Intern Med. 2010;49(3):231-5. doi: 10.2169/internalmedicine.49.2766. Epub 2010 Feb 1.
Gastrointestinal (GI) tract involvement of mantle cell lymphoma (MCL) presents as a variety of forms, ranging from multiple lymphomatous polyposis (MLP) to a slight mucosal change. We report 3 cases with GI tract involvement of MCL who were followed-up by endoscopy. The present study shows three new informations. MLP of the esophagus is rare, but it was observed in two of 3 patients who were extensively involved by MCL. Endoscopic follow-up in one patient suggested that lymphoma cells of MCL had invaded the lamina propria to submucosal layer before MLP developed. Two of the 3 cases showed a favorable clinical course with single-agent rituximab therapy.
套细胞淋巴瘤（MCL）累及胃肠道（GI）表现为多种形式，从多发性淋巴瘤性息肉病（MLP）到轻微的黏膜改变。我们报告3例MCL累及胃肠道且接受内镜随访的病例。本研究显示了三个新信息。食管的MLP罕见，但在3例广泛受累的MCL患者中有2例观察到。1例患者的内镜随访提示，MCL的淋巴瘤细胞在MLP形成之前已侵袭至固有层至黏膜下层。3例中的2例采用利妥昔单抗单药治疗显示出良好的临床病程。
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