Sil'kis I g
Zh Vyssh Nerv Deiat Im I P Pavlova. 2009 Nov-Dec;59(6):643-59.
A review. Possible mechanisms for generation of neural representations of object-place associations (NROPA) are analyzed in different parts of a neural network which include the hippocampus and parahippocampal complex. Streams of spatial and non-spatial information arrive to the hippocampus from the parahippocampal complex consisting of perirhinal, postrhinal and entorhinal cortical areas. We assume that, due to the absence of connections between lateral and medial areas of the entorhinal cortex, object-place associations are mostly formed in the hippocampus, but can also be generated in the perirhinal cortex due to existence of input from the postrhinal cortex. As both information streams converge on neurons of the dentate fascia and field CA3, a trisynaptic pathway through the hippocampus can play the basic role in the NROPA generation. Since the spatial information arrives in the neocortex and, therefore, reaches the parahippocampal complex and hippocampus approximately by 20 ms earlier than the "non-spatial" stream, only spatial information is processed firstly in the dentate fascia and field CA3. Generation of NROPA in the dentate fascia starts later, due to returning excitation from field CA3c. In the dentate fascia, signals from the NROPA are transferred into field CA3, where the activated neuronal pattern is superimposed by information arriving from the entorhinal cortex. As a result, more complex NROPA are formed in field CA3 and send signals to field CA1. In the dorsal (ventral) part of the field CA1, the activated neuronal pattern is superimposed by non-spatial (spatial) information arriving from the lateral (medial) part of the entorhinal cortex. As a result, a higher-order NROPA are generated. In the parahippocampal cortex, the generation ofNROPA can be a consequence of the activity transferred from the dorsal part of the hippocampal CA1 field.
一篇综述。在包括海马体和海马旁复合体在内的神经网络的不同部分，分析了物体 - 位置关联（NROPA）神经表征生成的可能机制。空间和非空间信息流从由嗅周皮质、嗅后皮质和内嗅皮质区域组成的海马旁复合体到达海马体。我们假设，由于内嗅皮质外侧和内侧区域之间缺乏连接，物体 - 位置关联大多在海马体中形成，但由于存在来自嗅后皮质的输入，也可在嗅周皮质中产生。由于这两种信息流都汇聚到齿状回和CA3区的神经元上，通过海马体的三突触通路在NROPA生成中可能起基本作用。由于空间信息到达新皮质，因此比“非空间”信息流大约早20毫秒到达海马旁复合体和海马体，所以只有空间信息首先在齿状回和CA3区进行处理。齿状回中NROPA的生成稍后开始，这是由于CA3c区的返回兴奋。在齿状回中，来自NROPA的信号被传递到CA3区，在那里激活的神经元模式被来自内嗅皮质的信息叠加。结果，在CA3区形成了更复杂的NROPA，并向CA1区发送信号。在CA1区的背侧（腹侧）部分，激活的神经元模式被来自内嗅皮质外侧（内侧）部分的非空间（空间）信息叠加。结果，产生了更高阶的NROPA。在海马旁皮质中，NROPA的生成可能是海马CA1区背侧传递的活动的结果。
