比较分析 MVA-CD40L 和 MVA-TRICOM 载体增强慢性淋巴细胞白血病（CLL）细胞免疫原性的研究。
Comparative analysis of MVA-CD40L and MVA-TRICOM vectors for enhancing the immunogenicity of chronic lymphocytic leukemia (CLL) cells.
机构信息
Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Leuk Res. 2010 Oct;34(10):1351-7. doi: 10.1016/j.leukres.2009.12.013. Epub 2010 Jan 31.
Abstract
Adenoviral transduction with CD40L and poxviral transduction with B7-1, ICAM-1, and LFA-3 (TRICOM) have been used to enhance the antigen-presenting capacity of chronic lymphocytic leukemia (CLL) cells. This study compares the same vector (modified vaccinia virus strain Ankara (MVA)) encoding CD40L or TRICOM for its ability to enhance the immunogenicity of CLL cells. CLL cells from some patients showed differential responses to each vector in terms of induction of autologous T-cell responses. This study supports the rationale for the use of CLL cells modified ex vivo with pre-specified recombinant MVA vectors as a whole tumor-cell vaccine for immunotherapy in CLL patients.
摘要
腺病毒转导 CD40L 和痘病毒转导 B7-1、ICAM-1 和 LFA-3（TRICOM）已被用于增强慢性淋巴细胞白血病（CLL）细胞的抗原呈递能力。本研究比较了相同的载体（编码 CD40L 或 TRICOM 的改良安卡拉痘苗病毒株（MVA））在增强 CLL 细胞免疫原性方面的能力。一些患者的 CLL 细胞对每种载体的反应存在差异，表现在诱导自体 T 细胞反应方面。这项研究支持了使用体外预先修饰的重组 MVA 载体修饰 CLL 细胞作为 CLL 患者免疫治疗的全肿瘤细胞疫苗的原理。
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