Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon 440-746, Republic of Korea.
Neurosci Lett. 2010 Mar 12;472(1):61-4. doi: 10.1016/j.neulet.2010.01.058. Epub 2010 Feb 1.
The transient receptor potential vanilloid type 1 (TRPV1) is a non-selective ligand-gated cationic channel. The distribution of TRPV1 mRNA in various regions of the brain has been successfully established. Methamphetamine (MAP) is a psychostimulant and a major drug of abuse in many parts of the world. The powerful rewarding properties of MAP are attributed to multiple pharmacological actions, but the mechanistic association between TRPV1 expression and MAP-induced drug addiction has not established. In the present study, we conducted a time-course analysis of TRPV1 mRNA levels in the frontal cortex, striatum, and hippocampus of mouse brain following repeated MAP (2mg/kg, i.p.) treatment. Our results demonstrate that expression of TRPV1 mRNA is significantly increased 1, 2, 6, 24, 48h, and 1 week after the last MAP treatment in the frontal cortex but not in the striatum or hippocampus. These data support a potential role for TRPV1 in the treatment of MAP-induced drug addiction.
瞬时受体电位香草酸亚型 1（TRPV1）是一种非选择性配体门控阳离子通道。TRPV1 mRNA 在大脑各个区域的分布已被成功确定。甲基苯丙胺（MAP）是一种兴奋剂，也是世界上许多地区的主要滥用药物。MAP 具有强大的奖赏特性，这归因于多种药理学作用，但 TRPV1 表达与 MAP 诱导的药物成瘾之间的机制关联尚未建立。在本研究中，我们对反复 MAP（2mg/kg，ip）处理后小鼠大脑前额叶皮层、纹状体和海马中的 TRPV1 mRNA 水平进行了时间进程分析。我们的结果表明，MAP 治疗后 1、2、6、24、48 小时和 1 周，TRPV1 mRNA 的表达在前额叶皮层中显著增加，但在纹状体或海马中没有增加。这些数据支持 TRPV1 在治疗 MAP 诱导的药物成瘾中的潜在作用。
