Centre for Vision Research, Department of Ophthalmology, Westmead Millennium Institute, University of Sydney, Australia.
Ann Epidemiol. 2010 Feb;20(2):129-35. doi: 10.1016/j.annepidem.2009.09.002.
We used a representative older population-based cohort to establish the predictors and impacts of tinnitus.
A total of 1,214 participants of the Blue Mountains Hearing Study were followed for 5 years (1997-1999 to 2002-2004). The presence of tinnitus was assessed by an audiologist-administered questionnaire. Hearing impairment was defined as the pure tone average (PTA)(0.5-4KHz)>25 dB HL, in the better ear. Quality of life was measured by use of the Short Form 36-item Health Survey (SF-36). Depression was assessed using either the SF-36 (Mental Health Index, subscale) and the Center for Epidemiologic Studies Depression Scale.
Symptomatic dizziness and hearing loss were significant risk factors for incident tinnitus, multivariable-adjusted odds ratio, 2.41 (95% confidence interval, 1.62-3.58) and odds ratio 2.31 (95% confidence interval, 1.46-3.66), respectively. Incident tinnitus cases demonstrated significantly lower mean SF-36 scores compared with subjects without tinnitus and were more likely to be depressed as assessed by both the Mental Health Index and Center for Epidemiologic Studies Depression Scale.
Incident tinnitus was predicted by two otological risk factors, dizziness and hearing loss. Temporal data documented diminished quality of life and psychological well-being in those subjects experiencing tinnitus. This finding highlights the importance of effective intervention strategies to prevent potentially debilitating morbidity associated with tinnitus.
我们使用具有代表性的老年人群队列来确定耳鸣的预测因素和影响。
1997-1999 年至 2002-2004 年对蓝山听力研究的 1214 名参与者进行了为期 5 年的随访。耳鸣的存在通过听力学家管理的问卷进行评估。听力障碍定义为纯音平均听力(0.5-4KHz)>25dBHL,较好耳。使用健康调查简表 36 项(SF-36)测量生活质量。抑郁使用 SF-36(心理健康指数,子量表)和流行病学研究中心抑郁量表进行评估。
症状性头晕和听力损失是耳鸣发生的显著危险因素,多变量调整后比值比分别为 2.41(95%置信区间,1.62-3.58)和 2.31(95%置信区间,1.46-3.66)。与无耳鸣的受试者相比,新发耳鸣病例的 SF-36 平均得分明显较低,并且根据心理健康指数和流行病学研究中心抑郁量表评估,更有可能抑郁。
两个耳科危险因素(头晕和听力损失)预测了新发耳鸣。时间数据记录了那些经历耳鸣的受试者生活质量和心理幸福感下降。这一发现强调了实施有效干预策略以预防与耳鸣相关的潜在致残发病率的重要性。