Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, Canada.
Parkinsonism Relat Disord. 2009 Dec;15 Suppl 4:S38-40. doi: 10.1016/S1353-8020(09)70833-8.
Recent PET studies in Parkinson's disease (PD) have shown that the progression of neurodegeneration follows an exponential decay pattern. Most of the damage to the nigrostriatal dopamine system occurs during the presymptomatic phase of the disease and the first few years following symptom onset. The progressive loss of dopaminergic neurons is accompanied by several functional adaptive changes in surviving nerve terminals, which lead to increased dopamine turnover and raise the risk of treatment-related motor complications. Younger PD patients seem to have more efficient compensatory mechanisms and a slower rate of progression of neurodegeneration.
最近帕金森病（PD）的 PET 研究表明，神经退行性变的进展遵循指数衰减模式。黑质纹状体多巴胺系统的大部分损伤发生在疾病的无症状期和症状出现后的最初几年。多巴胺能神经元的进行性丧失伴随着存活神经末梢的几种功能适应性变化，这导致多巴胺周转率增加，并增加与治疗相关的运动并发症的风险。年轻的 PD 患者似乎有更有效的补偿机制和更慢的神经退行性变进展速度。
