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Why doesn't imatinib cure chronic myeloid leukemia?
Oncologist. 2010;15(2):182-6. doi: 10.1634/theoncologist.2009-0297. Epub 2010 Feb 2.
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ApoptomiRs expression modulated by BCR-ABL is linked to CML progression and imatinib resistance.
Blood Cells Mol Dis. 2014 Jun-Aug;53(1-2):47-55. doi: 10.1016/j.bcmd.2014.02.008. Epub 2014 Mar 11.
5
Combining nilotinib and imatinib improves the outcome of imatinib-resistant blast phase CML.
Acta Haematol. 2012;127(3):152-5. doi: 10.1159/000333107. Epub 2012 Jan 27.
6
Targeted chronic myeloid leukemia therapy: Seeking a cure.
Am J Health Syst Pharm. 2007 Dec 15;64(24 Suppl 15):S9-15. doi: 10.2146/ajhp070482.
7
Imatinib mesylate in the treatment of chronic myelogenous leukemia.
Int J Hematol. 2004 Jun;79(5):411-9. doi: 10.1532/ijh97.04054.
8
Mechanisms and implications of imatinib resistance mutations in BCR-ABL.
Curr Opin Hematol. 2004 Jan;11(1):35-43. doi: 10.1097/00062752-200401000-00006.

引用本文的文献

2
I13 overrides resistance mediated by the T315I mutation in chronic myeloid leukemia by direct BCR-ABL inhibition.
Front Pharmacol. 2023 Apr 12;14:1183052. doi: 10.3389/fphar.2023.1183052. eCollection 2023.
3
Novel Experimental Therapies for Treatment of Pulmonary Arterial Hypertension.
J Exp Pharmacol. 2021 Aug 17;13:817-857. doi: 10.2147/JEP.S236743. eCollection 2021.
4
A Broad Overview of Signaling in -Negative Classic Myeloproliferative Neoplasms.
Cancers (Basel). 2021 Feb 26;13(5):984. doi: 10.3390/cancers13050984.
5
The Search for Disease-Modifying Therapies in Pulmonary Hypertension.
J Cardiovasc Pharmacol Ther. 2019 Jul;24(4):334-354. doi: 10.1177/1074248419829172. Epub 2019 Feb 17.
6
FZD7 regulates BMSCs-mediated protection of CML cells.
Oncotarget. 2016 Feb 2;7(5):6175-87. doi: 10.18632/oncotarget.6742.
7
Novel agent nitidine chloride induces erythroid differentiation and apoptosis in CML cells through c-Myc-miRNAs axis.
PLoS One. 2015 Feb 3;10(2):e0116880. doi: 10.1371/journal.pone.0116880. eCollection 2015.
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Pathways in pulmonary arterial hypertension: the future is here.
Eur Respir Rev. 2012 Dec 1;21(126):321-7. doi: 10.1183/09059180.00004812.

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A progenitor cell origin of myeloid malignancies.
Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16616-21. doi: 10.1073/pnas.0908107106. Epub 2009 Sep 21.
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Synergy between proteasome inhibitors and imatinib mesylate in chronic myeloid leukemia.
PLoS One. 2009 Jul 16;4(7):e6257. doi: 10.1371/journal.pone.0006257.
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Stem-cell driven cancer: "hands-off" regulation of cancer development.
Cell Cycle. 2009 May 1;8(9):1314-8. doi: 10.4161/cc.8.9.8217. Epub 2009 May 18.
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Translation of the Philadelphia chromosome into therapy for CML.
Blood. 2008 Dec 15;112(13):4808-17. doi: 10.1182/blood-2008-07-077958.
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Chronic myeloid leukemia stem cells.
J Clin Oncol. 2008 Jun 10;26(17):2911-5. doi: 10.1200/JCO.2008.17.5745.
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PML targeting eradicates quiescent leukaemia-initiating cells.
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