Nakamura Y, Yamamoto I, Fukuda S, Hashimoto T
Department of Pathology, St Mary's Hospital, Kurumeshi, Japan.
Arch Pathol Lab Med. 1991 Apr;115(4):372-6.
Pulmonary acinar development was assessed in 17 autopsy cases of pulmonary hypoplasia associated with diaphragmatic hernia. Morphologic examination was conducted by light and electron microscopy, and morphometric study was achieved by radial alveolar count and biochemical quantitation of surfactant phospholipid. In most cases of unilateral diaphragmatic hernia, the ipsilateral lung was underdeveloped morphologically and biochemically compared with the contralateral lung. However, both ipsilateral and contralateral lungs were well developed in some cases of unilateral diaphragmatic hernia. Thus, acinar development of hypoplastic lung in diaphragmatic hernia is varied. The influence of other conditions, such as oligohydramnios, polyhydramnios, and other anomalies that may influence retention of lung fluid or fetal respiratory movement, should be considered to assess the acinar development of hypoplastic lung in diaphragmatic hernia.
在17例与膈疝相关的肺发育不全尸检病例中评估了肺腺泡发育情况。通过光镜和电镜进行形态学检查，并通过放射状肺泡计数和表面活性物质磷脂的生化定量进行形态计量学研究。在大多数单侧膈疝病例中，与对侧肺相比，同侧肺在形态学和生化方面发育不全。然而，在一些单侧膈疝病例中，同侧肺和对侧肺均发育良好。因此，膈疝中发育不全肺的腺泡发育情况各不相同。在评估膈疝中发育不全肺的腺泡发育时，应考虑其他情况的影响，如羊水过少、羊水过多以及可能影响肺液潴留或胎儿呼吸运动的其他异常情况。
