雄激素与慢性阻塞性肺疾病。
Androgens and chronic obstructive pulmonary disease.
机构信息
Division of Internal Medicine, University Hospital of North Norway, University of Tromsø, Tromsø, Norway.
出版信息
Curr Opin Endocrinol Diabetes Obes. 2010 Jun;17(3):257-61. doi: 10.1097/MED.0b013e3283369da6.
PURPOSE OF REVIEW
To evaluate the recent literature on the effect of the use of androgens in men with chronic obstructive pulmonary disease (COPD).
RECENT FINDINGS
Men with COPD have been found to have reduced endogenous testosterone levels in some studies, and they also share several traits with hypogonadal men, such as loss of lean body mass and strength, suggesting that substitution with androgens might be a rational therapy. There are, however, only a few published placebo-controlled trials investigating the effects of androgens in men with COPD, and only one during the last 2 years. After a review of these manuscripts they were summarized.
SUMMARY
The effect of androgens in men with COPD is modest, and pulmonary function was in general not improved in men using androgens. The use of androgens to increase muscle mass and strength in patients participating in rehabilitation programs is promising, and also regarding the beneficial effects on sexuality. However, more research is needed to determine if androgen therapy could be a treatment option for men with COPD.
目的综述
评估雄激素在慢性阻塞性肺疾病（COPD）男性患者中的应用效果的最新文献。
最近的发现
一些研究发现 COPD 男性患者的内源性睾酮水平降低，而且他们还与性腺功能减退男性有一些共同特征，如瘦体重和力量丧失，这表明雄激素替代可能是一种合理的治疗方法。然而，只有少数已发表的安慰剂对照试验研究了雄激素在 COPD 男性中的作用，而且在过去 2 年中只有一项。在对这些文献进行综述后，对其进行了总结。
总结
雄激素对 COPD 男性的作用是适度的，一般来说，使用雄激素不会改善男性的肺功能。雄激素在参加康复计划的患者中增加肌肉质量和力量的应用有前景，对性功能也有有益影响。然而，需要进一步的研究来确定雄激素治疗是否可以成为 COPD 男性的一种治疗选择。
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