Corrêa Lívia L, Lima Giovanna A Balarini, Paiva Helena B de Melo, Silva Cíntia M Dos Santos, Cavallieri Suzana A, Miranda Luiz Carlos D de, Gadelha Mônica R
Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Arq Bras Endocrinol Metabol. 2009 Nov;53(8):963-8. doi: 10.1590/s0004-27302009000800009.
Acromegalic patients have an increased prevalence of prostatic disorders compared to age-matched healthy subjects. Increased size of the whole prostate or the transitional zone, together with an elevated incidence of other structural changes, such as nodules, cysts, and calcifications, have been reported. Prostate enlargement in young acromegalic patients with low testosterone levels due to central hypogonadism supports the hypothesis that chronic GH and IGF-I excess cause prostate hyperplasia. The relationship between prostatic carcinoma and acromegaly is, until now, only circumstantial. Long-term follow-up of these patients is necessary since epidemiologic studies showed association between serum IGF-I levels in the upper normal limit and prostate cancer in the general population. This review approaches prostate diseases in patients with acromegaly.
与年龄匹配的健康受试者相比，肢端肥大症患者前列腺疾病的患病率更高。据报道，整个前列腺或移行区体积增大，以及结节、囊肿和钙化等其他结构变化的发生率升高。由于中枢性性腺功能减退，年轻的肢端肥大症患者睾酮水平较低，前列腺增大，这支持了慢性生长激素（GH）和胰岛素样生长因子-I（IGF-I）过量导致前列腺增生的假说。迄今为止，前列腺癌与肢端肥大症之间的关系只是间接的。对这些患者进行长期随访是必要的，因为流行病学研究表明，一般人群中血清IGF-I水平处于正常上限与前列腺癌之间存在关联。本文综述了肢端肥大症患者的前列腺疾病。
