Netherlands Institute of Mental Health and Addiction, 3500 AS Utrecht, The Netherlands.
Int Psychogeriatr. 2010 Jun;22(4):572-81. doi: 10.1017/S104161020999175X. Epub 2010 Feb 4.
We developed an indicated preventive life-review course, "Looking for Meaning", based on the assumption that reminiscence styles influence coping with depressive symptoms. This study describes the impact of this course in a pragmatic randomized controlled trial.
Inclusion criteria were >50 years, a score of 5 or higher on the Center for Epidemiological Studies Depression Scale (CES-D), and no depressive disorder or psychotropic or psychological treatment. Participants were randomized and stratified by gender: the experimental group (N = 83) was offered the course and the comparison group (N = 88) a movie. There were three measurements: pre-treatment, post-treatment and 6 months after post-treatment. Depressive symptoms constituted the primary outcome. Secondary outcomes were anxiety symptoms, satisfaction with life, mastery and reminiscence styles. All analyses were conducted according to the intention-to-treat principle. Missing values were replaced by regression imputation.
The course reduced depressive symptoms, a decrease that was retained during follow-up. A significant between-group effect size was found (d = 0.58). There was also a reduction in symptoms of anxiety; however, the comparison group showed the same reduction, resulting in a small between-group effect size. Gender and level of depressive symptoms were found to be prognostic factors for the change in depressive symptoms; age was not. Post hoc analyses showed significant between-group effect sizes for females and those with a score above the cut-off of the CES-D.
The course "Looking for Meaning" can be recommended for people aged over 50 years, females and older adults with a clinically relevant level of depressive symptoms (above cut-off) in particular.
我们开发了一种有针对性的预防生活回顾课程,即“寻找意义”,该课程基于这样一种假设,即怀旧风格会影响应对抑郁症状的方式。本研究在一项实用随机对照试验中描述了该课程的影响。
纳入标准为年龄>50 岁,流行病学研究中心抑郁量表(CES-D)得分为 5 或更高,且无抑郁障碍或精神药物或心理治疗史。参与者按性别随机分层:实验组(N=83)接受课程,对照组(N=88)观看电影。共有 3 次测量:治疗前、治疗后和治疗后 6 个月。抑郁症状是主要结局。次要结局是焦虑症状、生活满意度、掌控感和怀旧风格。所有分析均按照意向治疗原则进行。缺失值由回归插补法替换。
该课程可减少抑郁症状,且这种减少在随访期间得以维持。发现组间存在显著的效应大小(d=0.58)。焦虑症状也有所减少;然而,对照组也表现出同样的减少,导致组间效应大小较小。性别和抑郁症状的严重程度被发现是抑郁症状变化的预后因素;年龄不是。事后分析显示,对于女性和 CES-D 得分高于临界值的人群,组间存在显著的效应大小。
对于年龄在 50 岁以上、女性以及年龄较大且抑郁症状严重(高于临界值)的人群,特别是推荐使用“寻找意义”课程。