嵌段共聚物对模型佐剂的增溶作用。

Solubilisation of model adjuvants by Pluronic block copolymers.

机构信息

School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.

出版信息

J Colloid Interface Sci. 2010 Apr 15;344(2):438-46. doi: 10.1016/j.jcis.2010.01.005. Epub 2010 Jan 11.

DOI:10.1016/j.jcis.2010.01.005

PMID:20129623

Abstract

The effect of two model adjuvants (benzyl benzoate and benzyl alcohol) on the structure and dynamics of three Pluronic triblock copolymers (P85, P105 and F127) was studied using small-angle neutron scattering and pulsed-field gradient NMR. The two adjuvants studied have different aqueous solubilities. It was found that both adjuvants promoted the micellisation of the Pluronic block copolymers. In addition they lead to a swelling of the micelles, as shown by small-angle neutron scattering. From the pulsed-field gradient NMR results it was possible to determine the amount of adjuvant bound to the micelles.

摘要

使用小角中子散射和脉冲梯度 NMR 研究了两种模型佐剂（苯甲酸苄酯和苄醇）对三种泊洛沙姆嵌段共聚物（P85、P105 和 F127）结构和动力学的影响。研究的两种佐剂在水中的溶解度不同。结果发现，两种佐剂都促进了泊洛沙姆嵌段共聚物的胶束化。此外，正如小角中子散射所表明的那样，它们还导致胶束溶胀。从脉冲梯度 NMR 的结果可以确定结合到胶束上的佐剂的量。