Department of Anaesthesiology and Intensive Care Medicine, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
J Neuroimmunol. 2010 Mar 30;220(1-2):108-13. doi: 10.1016/j.jneuroim.2010.01.007. Epub 2010 Feb 2.
Glial cell line-derived neurotrophic factor (GDNF) is involved in inflammation and pain, roles which remain to be delineated clinically. We aimed to evaluate the role of central nervous and peripheral GDNF in long-term pain patients and in controls by analysing intrathecal and blood concentrations of GDNF. Simultaneous measurements of pro-inflammatory cytokines IL-1beta, TNF-alpha and IL-6, anti-inflammatory cytokine IL-10 and chemokine IL-8 served to define inflammatory responses. Generally, blood levels of GDNF were higher than corresponding intrathecal levels. Pain was associated with levels of GDNF that were increased intrathecally, but decreased in blood. IL-8 was uniformly higher in pain patients.
胶质细胞源性神经营养因子（GDNF）参与炎症和疼痛，但其临床作用仍有待阐明。我们旨在通过分析鞘内和血液中的 GDNF 浓度，评估中枢和外周 GDNF 在长期疼痛患者和对照者中的作用。同时测量促炎细胞因子 IL-1β、TNF-α和 IL-6、抗炎细胞因子 IL-10 和趋化因子 IL-8，以定义炎症反应。一般来说，GDNF 的血液水平高于相应的鞘内水平。疼痛与鞘内 GDNF 水平升高有关，而血液中 GDNF 水平降低。IL-8 在疼痛患者中普遍升高。
