Department, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy.
Auton Neurosci. 2010 Jun 24;155(1-2):98-103. doi: 10.1016/j.autneu.2010.01.002. Epub 2010 Feb 2.
Although the pathophysiology of vasovagal syncope is not completely understood, the involvement of sympathetic nervous system alterations has been suggested. Since predisposition to fainting during orthostatic challenge may be associated with genetic variations, we sought to explore the role of genetic polymorphisms affecting sympathetic nervous system function in the susceptibility to tilt-induced vasovagal syncope. We genotyped 129 subjects with recurrent unexplained syncope who underwent tilt testing, and investigated the recurrence of syncope. The analysed polymorphisms were Arg492Cys (ADRA1A gene), Ser49Gly and Arg389Gly (ADRB1), Arg16Gly and Gln27Glu (ADRB2), 825C/T (GNB3), -1021C/T (DBH) and S/L (SLC6A4). No association of the aforementioned genetic variants with both tilt test outcomes and new syncopal episodes during follow-up was found. None of the considered polymorphisms influencing sympathetic activity is a major risk factor for vasovagal syncope in Italian patients.
虽然血管迷走性晕厥的病理生理学尚未完全阐明，但已提出交感神经系统改变的参与。由于在直立挑战期间晕厥的倾向可能与遗传变异有关，我们试图探讨影响交感神经系统功能的遗传多态性在倾斜诱导的血管迷走性晕厥易感性中的作用。我们对 129 名接受倾斜试验的复发性不明原因晕厥患者进行了基因分型，并研究了晕厥的复发情况。分析的多态性是 Arg492Cys（ADRA1A 基因）、Ser49Gly 和 Arg389Gly（ADRB1）、Arg16Gly 和 Gln27Glu（ADRB2）、825C/T（GNB3）、-1021C/T（DBH）和 S/L（SLC6A4）。上述遗传变异与倾斜试验结果以及随访中新的晕厥发作之间没有关联。影响交感活性的上述多态性均不是意大利患者血管迷走性晕厥的主要危险因素。
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