胰腺腺泡细胞癌在患有慢性胰腺炎的年轻患者中。
Acinar cell carcinoma of the pancreas in a young patient with chronic pancreatitis.
机构信息
Department of Pathology, Mongi Slim Hospital, 2046 Sidi Daoued La Marsa, Tunisia.
出版信息
Hepatobiliary Pancreat Dis Int. 2010 Feb;9(1):103-6.
BACKGROUND
Acinar cell carcinoma (ACC) is a rare malignancy of the pancreas arising from acinar cells. Unlike ductal adenocarcinoma, this tumor rarely presents with pancreatitis.
METHODS
We present a case of ACC associated with chronic calcifying pancreatitis, and a review of the literature focusing on diagnosis and management.
RESULTS
A 43-year-old man was proposed for Wirsungojejunal derivation for chronic pancreatitis. Histopathological examination of the tissue extracted revealed an ACC. Duodenopancreatectomy was performed. Six months post-operatively, the patient developed hepatic metastasis and was treated with gemcitabine as palliative chemotherapy.
CONCLUSIONS
The clinical presentation of ACC of the pancreas is not specific and the tumor can be under-diagnosed when associated with chronic pancreatitis. Data regarding course, treatment, and prognosis of this tumor are generally lacking.
背景
胰腺腺泡细胞癌（ACC）是一种罕见的胰腺恶性肿瘤，起源于腺泡细胞。与导管腺癌不同，这种肿瘤很少伴有胰腺炎。
方法
我们报告一例与慢性钙化性胰腺炎相关的 ACC，并对诊断和治疗方面的文献进行了回顾。
结果
一名 43 岁男性因慢性胰腺炎被提议行 Wirsungojejunal 转流术。所取出组织的组织病理学检查显示为 ACC。行胰十二指肠切除术。术后 6 个月，患者出现肝转移，并接受吉西他滨姑息化疗。
结论
胰腺 ACC 的临床表现不具有特异性，当与慢性胰腺炎相关时，肿瘤可能会被漏诊。关于该肿瘤病程、治疗和预后的数据通常较为缺乏。
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