Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina 27715, USA.
Thromb Haemost. 2010 Mar;103(3):586-95. doi: 10.1160/TH09-10-0716. Epub 2010 Feb 2.
Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, and an unparalleled opportunity for accelerating the development and clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.
抗血栓治疗在急性血栓性疾病的管理中受到了我们当前对血小板生物学、凝血蛋白酶和血管科学的理解的积极推动和指导。一个基于生物化学、酶学和血小板及组织因子暴露细胞的细胞事件的、可靠的凝血转化平台，引入了基本结构、机制清晰性，并为加速疾病和患者特异性治疗的开发和临床研究提供了无与伦比的机会。在本综述中，我们在围绕核酸作为抗血栓药物的观察的基础上进行了实质性的扩展。
