Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India.
J Biochem Mol Toxicol. 2010 Jul-Aug;24(4):270-7. doi: 10.1002/jbt.20335.
With the increasing evidence of protease involvement in several diseases, novel strategies for drug development involve the use of protease inhibitors (PIs). The local balance between protease inhibitors and proteases is an important determinant of the occurrence and progression of a particular disease. Hence, enzymes and their cognate inhibitors are finding their applications as diagnostic and prognostic markers. PIs are widely implicated for their use in host defense against infection, tissue repair and matrix production, blood coagulation, cancer, and they are, therefore, the current focus as therapeutic alternatives for major diseases such as AIDS and Alzheimer's diseases. This review is a brief summary of the varied role of protein protease inhibitors in controlling the activity of aberrant enzymes in several diseases afflicting mankind today.
随着越来越多的证据表明蛋白酶参与了多种疾病，开发新药的新策略涉及使用蛋白酶抑制剂 (PIs)。蛋白酶抑制剂和蛋白酶之间的局部平衡是特定疾病发生和发展的重要决定因素。因此，酶及其同源抑制剂正在作为诊断和预后标志物得到应用。PI 在宿主抗感染、组织修复和基质生成、血液凝固、癌症等方面的应用广泛，因此，它们是治疗艾滋病和阿尔茨海默病等重大疾病的治疗替代品的当前重点。本文简要总结了蛋白蛋白酶抑制剂在控制当今人类多种疾病中异常酶活性方面的多种作用。
