选择性和非选择性磷酸二酯酶抑制剂对小鼠吞噬细胞的影响。
The effects of selective and nonselective phosphodiesterase inhibitors on phagocytic cells in mice.
机构信息
Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.
出版信息
Immunopharmacol Immunotoxicol. 2010 Sep;32(3):507-13. doi: 10.3109/08923970903359850.
Milrinone (1 mg/kg i.m.), sildenafil (1 mg/kg p.o), and aminophylline (20 mg/kg i.m.) were administered to mice once or five times. The drugs increased the production of IL-1beta and NO by peritoneal macrophages. Milrinone or aminophylline did not change the percentage of phagocytosing cells. A single administration of sildenafil increased the percentage of phagocytosing granulocytes (after 12 h). Sildenafil administered five times decreased the percentage of phagocytosing monocytes (72 h after the last dose). A single administration of the drugs did not change the oxidative burst activity. PDE inhibitors administered five times temporarily enhanced the percentage of cells producing reactive oxidants.
米力农（1mg/kg，肌肉注射）、西地那非（1mg/kg，口服）和氨茶碱（20mg/kg，肌肉注射）分别给小鼠给药一次或五次。这些药物增加了腹腔巨噬细胞产生的白细胞介素-1β和一氧化氮。米力农或氨茶碱不改变吞噬细胞的百分比。单次给予西地那非增加了吞噬粒细胞的百分比（在 12 小时后）。五次给予西地那非可降低吞噬单核细胞的百分比（在最后一次给药后 72 小时）。药物单次给药不改变氧化爆发活性。五倍剂量的 PDE 抑制剂暂时增强了产生活性氧的细胞的百分比。
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