Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.
Immunopharmacol Immunotoxicol. 2010 Sep;32(3):507-13. doi: 10.3109/08923970903359850.
Milrinone (1 mg/kg i.m.), sildenafil (1 mg/kg p.o), and aminophylline (20 mg/kg i.m.) were administered to mice once or five times. The drugs increased the production of IL-1beta and NO by peritoneal macrophages. Milrinone or aminophylline did not change the percentage of phagocytosing cells. A single administration of sildenafil increased the percentage of phagocytosing granulocytes (after 12 h). Sildenafil administered five times decreased the percentage of phagocytosing monocytes (72 h after the last dose). A single administration of the drugs did not change the oxidative burst activity. PDE inhibitors administered five times temporarily enhanced the percentage of cells producing reactive oxidants.
米力农（1mg/kg，肌肉注射）、西地那非（1mg/kg，口服）和氨茶碱（20mg/kg，肌肉注射）分别给小鼠给药一次或五次。这些药物增加了腹腔巨噬细胞产生的白细胞介素-1β和一氧化氮。米力农或氨茶碱不改变吞噬细胞的百分比。单次给予西地那非增加了吞噬粒细胞的百分比（在 12 小时后）。五次给予西地那非可降低吞噬单核细胞的百分比（在最后一次给药后 72 小时）。药物单次给药不改变氧化爆发活性。五倍剂量的 PDE 抑制剂暂时增强了产生活性氧的细胞的百分比。
