Vaughan Deirdre F, Clay Hodgin E, Hosgood Giselle L, Bernstein Joseph A
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Vet Dermatol. 2010 Apr;21(2):166-74. doi: 10.1111/j.1365-3164.2009.00775.x. Epub 2010 Feb 2.
The importance of cellular infiltrates in tissues has been investigated as a diagnostic tool, mechanism of pathogenesis, and prognostic indicator in certain human diseases. Eosinophils, in particular, have a distinct role in the development of cutaneous lesions in human autoimmune diseases. Identification of an eosinophilic infiltrate can aid the diagnosis of immunobullous disease in the early stages of the disease process. In canine pemphigus foliaceus, eosinophils are present to a variable degree within lesional tissue. This study retrospectively evaluated 40 dogs with pemphigus foliaceus, and examined clinical and histologic features and final outcomes in cases with and without eosinophilic infiltrates. Twenty-five of 40 dogs (63%) had an eosinophilic infiltrate in either the pustules/crust, follicular infundibulum or dermis. There was no statistically significant difference in clinical distribution or appearance of dermatological lesions, response to treatment, or disease outcome in dogs with or without an eosinophilic infiltrate. However, dogs with concurrent disease were significantly more likely to have an eosinophilic infiltrate (P = 0.01). Dogs with adverse effects associated with immunosuppressive therapy were significantly more likely to have an eosinophilic infiltrate (P = 0.05). Fifteen of 40 dogs (38%) had a history of allergic disease and a significantly higher proportion of these dogs had an eosinophilic infiltrate (P = 0.04). An eosinophilic infiltrate was found in more than half of the dogs in this study. These findings justify further studies to investigate the role of eosinophils in the pathogenesis, therapy and prognosis in dogs with pemphigus foliaceus.
细胞浸润在组织中的重要性已作为一种诊断工具、发病机制及某些人类疾病的预后指标进行了研究。特别是嗜酸性粒细胞，在人类自身免疫性疾病皮肤病变的发展中具有独特作用。嗜酸性粒细胞浸润的识别有助于在疾病进程的早期诊断免疫性大疱性疾病。在犬落叶型天疱疮中，嗜酸性粒细胞在病变组织中呈不同程度存在。本研究回顾性评估了40只患有落叶型天疱疮的犬，检查了有或无嗜酸性粒细胞浸润病例的临床和组织学特征及最终结局。40只犬中有25只（63%）在脓疱/痂皮、毛囊漏斗部或真皮中有嗜酸性粒细胞浸润。有或无嗜酸性粒细胞浸润的犬在皮肤病损的临床分布或外观、对治疗的反应或疾病结局方面无统计学显著差异。然而，并发疾病的犬更有可能有嗜酸性粒细胞浸润（P = 0.01）。与免疫抑制治疗相关有不良反应的犬更有可能有嗜酸性粒细胞浸润（P = 0.05）。40只犬中有15只（38%）有过敏疾病史，这些犬中有嗜酸性粒细胞浸润的比例显著更高（P = 0.04）。本研究中超过一半的犬发现有嗜酸性粒细胞浸润。这些发现证明有必要进一步研究以探讨嗜酸性粒细胞在犬落叶型天疱疮发病机制、治疗及预后中的作用。
