Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Belgium.
Prog Neurobiol. 2010 Jul;91(3):189-99. doi: 10.1016/j.pneurobio.2010.01.011. Epub 2010 Feb 4.
Evidence accumulates for a key role of the beta(2)-adrenergic receptors in the many homeostatic and neuroprotective functions of astrocytes, including glycogen metabolism, regulation of immune responses, release of neurotrophic factors, and the astrogliosis that occurs in response to neuronal injury. A dysregulation of the astrocytic beta(2)-adrenergic-pathway is suspected to contribute to the physiopathology of a number of prevalent and devastating neurological conditions such as multiple sclerosis, Alzheimer's disease, human immunodeficiency virus encephalitis, stroke and hepatic encephalopathy. In this review we focus on the physiological functions of astrocytic beta(2)-adrenergic receptors, and their possible impact in disease states.
越来越多的证据表明，β2-肾上腺素能受体在星形胶质细胞的许多稳态和神经保护功能中起着关键作用，包括糖元代谢、免疫反应调节、神经营养因子释放以及神经元损伤时发生的星形胶质细胞增生。β2-肾上腺素能通路的失调被怀疑是导致多种常见且破坏性的神经疾病的病理生理学的原因，如多发性硬化症、阿尔茨海默病、人类免疫缺陷病毒脑炎、中风和肝性脑病。在这篇综述中，我们重点介绍星形胶质细胞β2-肾上腺素能受体的生理功能及其在疾病状态下的可能影响。
