Department of Pharmacology and Pharmacotherapy, Semmelweis University, Faculty of Medicine, Nagyvarad ter 4., 1089 Budapest, Hungary.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Apr 16;34(3):500-5. doi: 10.1016/j.pnpbp.2010.02.004. Epub 2010 Feb 4.
Premenstrual symptoms affect the majority of healthy women. Premenstrual symptomatology has earlier been linked to stress and a state-like alteration in the perception of life events in the late-luteal phase of the menstrual cycle. We hypothesised that there is also a trait-like negative bias in the perception of life events evident throughout the whole cycle which is associated with the likelihood to manifest more marked symptoms in the late-luteal phase of the cycle.
88 healthy women completed the PRISM calendar for three consecutive cycles and the Objective and Subjective Event Checklist during the follicular phase of the first cycle. Association between PRISM score change from the follicular through the late-luteal phase and life event variables was investigated by Generalized Linear Model Analysis (GENMOD).
The PRISM score change showed a significant negative association with the ratio of positive subjective life events and a significant positive association with the ratio of negative subjective life events. There were no significant results in case of the objective life events.
Our results indicate that women manifesting a more marked increase of symptoms from the late follicular through the late-luteal phase of the menstrual cycle are more likely to notice negative subjective life events and less likely to notice positive subjective life events. This suggest a trait-like negative bias in the perception of life events present throughout the whole reproductive cycle which may play an important role in the emergence of premenstrual symptoms.
经前期症状影响大多数健康女性。经前期症状学与压力有关，并且在月经周期黄体晚期，生活事件的感知呈状态样改变。我们假设，在整个周期中，生活事件的感知也存在一种特质性的负性偏差，这种偏差与在黄体晚期表现出更明显症状的可能性相关。
88 名健康女性连续三个周期完成 PRISM 日历，在第一个周期的卵泡期完成客观和主观事件检查表。通过广义线性模型分析（GENMOD），研究从卵泡期到黄体晚期 PRISM 评分变化与生活事件变量之间的关联。
PRISM 评分变化与正性主观生活事件的比值呈显著负相关，与负性主观生活事件的比值呈显著正相关。客观生活事件无显著结果。
我们的研究结果表明，从卵泡晚期到黄体晚期，症状明显加重的女性更有可能注意到负性主观生活事件，而不太可能注意到正性主观生活事件。这表明在整个生殖周期中，生活事件的感知存在一种特质性的负性偏差，这可能在经前期症状的出现中起着重要作用。
