Department of Home Economic, Faculty of Specific Education, Alexandria University, Alexandria, Egypt.
Food Chem Toxicol. 2010 May;48(5):1152-9. doi: 10.1016/j.fct.2010.02.002. Epub 2010 Feb 4.
The objective of the current study was to analyze the reproductive toxicity caused by lambda-cyhalothrin (LCT) in male rabbits, and to evaluate the possible protective effect of vitamin E (Vit. E) as antioxidant. Animals were orally administered their respective doses of LCT every other day and given drinking water supplemented with vitamin E for 16 weeks. Results showed that semen quality was deteriorated following treatment with LCT. Also, testosterone levels, body weight (BW), feed intake (FI), and relative testes (RTW) and epididymis (REW) weights were significantly decreased. Concentrations of thiobarbituric acid-reactive substances (TBARS) were significantly increased in seminal plasma of rabbits treated with LCT compared with control. While, activities of glutathione S-transferase (GST), transaminases and acid phosphatase (AcP) were significantly decreased. Vitamin E alone significantly increased testosterone levels, BW, FI, RTW, REW, semen characteristics and seminal plasma enzymes, and decreased the levels of TBARS. Also, the present study showed that vitamin E might be effective against LCT-induced reproductive toxicity. It was suggested that LCT exerted a significant adverse effect on reproductive performance of male rabbits. Furthermore, vitamin E antagonized the toxic effects of LCT and improved semen quality of male rabbit.
本研究旨在分析（lambda）-氯氰菊酯（LCT）对雄性兔的生殖毒性，并评估维生素 E（Vit. E）作为抗氧化剂的可能保护作用。动物每隔一天口服给予相应剂量的 LCT，并给予补充维生素 E 的饮用水 16 周。结果表明，LCT 处理后精液质量恶化。此外，睾酮水平、体重（BW）、采食量（FI）和相对睾丸（RTW）和附睾（REW）重量显著降低。与对照组相比，LCT 处理的兔精液中硫代巴比妥酸反应物质（TBARS）的浓度显著升高。而谷胱甘肽 S-转移酶（GST）、转氨酶和酸性磷酸酶（AcP）的活性显著降低。单独使用维生素 E 可显著提高睾酮水平、BW、FI、RTW、REW、精液特性和精液酶水平，并降低 TBARS 水平。此外，本研究表明维生素 E 可能对 LCT 诱导的生殖毒性有效。提示 LCT 对雄性兔的生殖性能有显著的不良影响。此外，维生素 E 拮抗了 LCT 的毒性作用，改善了雄性兔的精液质量。
