Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
Biochem Biophys Res Commun. 2010 Mar 12;393(3):410-3. doi: 10.1016/j.bbrc.2010.01.134. Epub 2010 Feb 6.
Incretin secretion and effect on insulin secretion are not fully understood in patients with type 2 diabetes. We investigated incretin and insulin secretion after meal intake in obese and non-obese Japanese patients with type 2 diabetes compared to non-diabetic subjects. Nine patients with type 2 diabetes and 5 non-diabetic subjects were recruited for this study. Five diabetic patients were obese (BMI > or = 25) and 4 patients were non-obese (BMI < 25). In response to a mixed meal test, the levels of immunoreactive insulin during 15-90 min and C-peptide during 0-180 min in non-obese patients were significantly lower than those in obese patients. Total GLP-1 and active GIP levels showed no significant difference between obese and non-obese patients throughout the meal tolerance test. In addition, there were no significant differences between diabetic patients and non-diabetic subjects. In conclusion, incretin secretion does not differ between Japanese obese and non-obese patients with type 2 diabetes and non-diabetic subjects.
在 2 型糖尿病患者中，肠降血糖素的分泌及其对胰岛素分泌的作用尚不完全清楚。我们研究了肥胖和非肥胖的 2 型糖尿病日本患者与非糖尿病患者餐后肠降血糖素和胰岛素的分泌情况。本研究共招募了 9 例 2 型糖尿病患者和 5 例非糖尿病患者。5 例糖尿病患者肥胖（BMI≥25），4 例患者非肥胖（BMI＜25）。在混合餐试验中，非肥胖患者的 15-90 分钟时的胰岛素免疫反应水平和 0-180 分钟时的 C 肽水平明显低于肥胖患者。在整个耐餐试验中，肥胖和非肥胖患者的总 GLP-1 和活性 GIP 水平没有显著差异。此外，糖尿病患者与非糖尿病患者之间也没有显著差异。综上所述，肠降血糖素的分泌在肥胖和非肥胖的 2 型糖尿病日本患者与非糖尿病患者之间没有差异。
