信号通路的交叉调控：以核激素受体和经典 Wnt 通路为例。
Cross-regulation of signaling pathways: an example of nuclear hormone receptors and the canonical Wnt pathway.
机构信息
Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road, NW, Washington, DC 20057, USA.
出版信息
Exp Cell Res. 2010 Jul 1;316(11):1763-72. doi: 10.1016/j.yexcr.2010.02.001. Epub 2010 Feb 6.
Abstract
Predicting the potential physiological outcome(s) of any given molecular pathway is complex because of cross-talk with other pathways. This is particularly evident in the case of the nuclear hormone receptor and canonical Wnt pathways, which regulate cell growth and proliferation, differentiation, apoptosis, and metastatic potential in numerous tissues. These pathways are known to intersect at many levels: in the intracellular space, at the membrane, in the cytoplasm, and within the nucleus. The outcomes of these interactions are important in the control of stem cell differentiation and maintenance, feedback loops, and regulating oncogenic potential. The aim of this review is to demonstrate the importance of considering pathway cross-talk when predicting functional outcomes of signaling, using nuclear hormone receptor/canonical Wnt pathway cross-talk as an example.
摘要
由于与其他途径的相互作用，预测任何给定分子途径的潜在生理结果都很复杂。在核激素受体和经典 Wnt 途径的情况下尤其如此，这些途径调节细胞生长和增殖、分化、凋亡和许多组织中的转移潜能。这些途径在多个水平上被认为是相互交叉的：在细胞内空间、膜上、细胞质中和细胞核内。这些相互作用的结果对于控制干细胞分化和维持、反馈回路以及调节致癌潜能非常重要。本综述的目的是展示在预测信号转导的功能结果时考虑途径相互作用的重要性，以核激素受体/经典 Wnt 途径相互作用为例。
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2
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3
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J Clin Oncol. 2009 Jul 1;27(19):3161-8. doi: 10.1200/JCO.2008.18.2485. Epub 2009 May 26.
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