Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA.
Nat Neurosci. 2010 Mar;13(3):284-6. doi: 10.1038/nn.2497. Epub 2010 Feb 7.
To assess the importance of brain cytochrome P450 (P450) activity in mu opioid analgesic action, we generated a mutant mouse with brain neuron-specific reductions in P450 activity; these mice showed highly attenuated morphine antinociception compared with controls. Pharmacological inhibition of brain P450 arachidonate epoxygenases also blocked morphine antinociception in mice and rats. Our findings indicate that a neuronal P450 epoxygenase mediates the pain-relieving properties of morphine.
为了评估脑细胞色素 P450（P450）活性在μ阿片类镇痛药作用中的重要性，我们生成了一种突变小鼠，其脑神经元中的 P450 活性降低；与对照组相比，这些小鼠的吗啡镇痛作用明显减弱。脑 P450 花生四烯酸环氧合酶的药理学抑制也阻断了小鼠和大鼠的吗啡镇痛作用。我们的研究结果表明，神经元 P450 环氧合酶介导了吗啡的止痛作用。
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