Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie der LMU, Müchen, Germany.
Dtsch Arztebl Int. 2010 Jan;107(3):23-9. doi: 10.3238/arztebl.2010.0023. Epub 2010 Jan 15.
Adverse drug events (ADE) are a common cause of hospital admission as well as a common complication of inpatient care. The current reporting systems in Germany are of only limited use for the identification of ADE. The aim of this study is to examine the potential usefulness of ICD-10 coded diagnoses in routine hospital data for the identification of ADE.
The common, major manifestations of ADE were mapped to the ICD-10-GM, and categories in the ICD-10-GM for which a possible causal relationship with medications is explicitly mentioned were included as well. A total of 505 relevant ICD-10-GM codes were identified. An evaluation was carried out on the basis of an aggregated data set from eleven million inpatients treated in 2006.
0.7% of hospital admissions were revealed by routine data to be causally related to the administration of a drug. In 5.3% of admissions, there was at least a reason to suspect such a causal relation. Furthermore, one of the 505 relevant codes was found to be present in 9.0% of the secondary diagnoses.
The available ICD-10-GM codes for manifestations of ADE are used in routine hospital data in Germany. Their usefulness for the identification of ADE should be better exploited. Our results and other relevant published literature imply that this procedure will result in both false-positive and false-negative findings, which will have to be taken into account as well.
药物不良事件（ADE）是导致住院的常见原因，也是住院治疗的常见并发症。德国目前的报告系统在识别 ADE 方面的作用有限。本研究旨在探讨常规医院数据中 ICD-10 编码诊断在识别 ADE 方面的潜在用途。
将 ADE 的常见主要表现映射到 ICD-10-GM，并纳入 ICD-10-GM 中明确提到与药物可能存在因果关系的类别。共确定了 505 个相关的 ICD-10-GM 代码。基于 2006 年 1100 万住院患者的汇总数据集进行了评估。
常规数据显示，0.7%的住院与药物治疗有关。在 5.3%的住院中，至少有理由怀疑存在这种因果关系。此外，在 505 个相关代码中，有一个出现在 9.0%的次要诊断中。
德国常规医院数据中使用了 ADE 表现的可用 ICD-10-GM 代码。应更好地利用其识别 ADE 的用途。我们的结果和其他相关已发表的文献表明，该程序将导致假阳性和假阴性的发现，这也必须加以考虑。
