Li Keshi, Guo Junming, Xiao Bingxiu, Zhou Hui
Department of Biochemistry, Ningbo University School of Medicine, Ningbo, Zhejiang, 315211 P.R. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010 Feb;27(1):56-9. doi: 10.3760/cma.j.issn.1003-9406.2010.01.012.
Non-coding RNAs (ncRNAs) are RNA molecules that exclude mRNA, tRNA and rRNA, and do not code proteins. ncRNAs play a various roles in the regulation of important vital activities in many organisms such as bacteria, fungi and mammals. Recent researches have shown that ncRNAs, as oncogenes or tumor suppressor genes, have tremendous impacts on the occurrence and development of tumors. Meanwhile, ncRNAs have become a new type of tumor markers and new targets for cancer treatment. This review describes the research progresses of ncRNAs such as small interference RNA and microRNA, and their roles in carcinogenesis.
非编码RNA(ncRNAs)是排除信使核糖核酸(mRNA)、转运核糖核酸(tRNA)和核糖体核糖核酸(rRNA)且不编码蛋白质的RNA分子。ncRNAs在许多生物体(如细菌、真菌和哺乳动物)重要生命活动的调控中发挥着多种作用。最近的研究表明,ncRNAs作为癌基因或肿瘤抑制基因,对肿瘤的发生和发展有巨大影响。同时,ncRNAs已成为一种新型肿瘤标志物和癌症治疗的新靶点。本文综述了小干扰RNA和微小RNA等ncRNAs的研究进展及其在致癌过程中的作用。