Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York 10029, USA.
Dev Dyn. 2010 Mar;239(3):875-84. doi: 10.1002/dvdy.22235.
Correct tissue patterning during development involves multiple morphogenetic events that include specification of different cell fates, cell proliferation, cell death, and coordinated changes in cell shape, position, and adhesion. Here, we use the Drosophila retina to explore the molecular mechanisms that regulate and integrate these various events. In a previous report, we found that wingless (wg) was required to induce a previously unknown surge of cell death ("early death") in the pupal retina. Here, we show that wg is also required to induce the more widely studied mid-pupal cell death ("late death") in a process that involves regulation of DIAP1. Furthermore, our data suggest that wg has a previously unreported role in specifying the glial-like cone cells. This activity requires canonical Wg signaling and is linked with Notch pathway activity. Our work broadens the role of canonical Wg signaling to encompass multiple patterning steps in the emerging Drosophila retina.
在发育过程中正确的组织模式涉及多个形态发生事件，包括不同细胞命运的指定、细胞增殖、细胞死亡以及细胞形状、位置和黏附的协调变化。在这里，我们使用果蝇的视网膜来探索调节和整合这些各种事件的分子机制。在之前的一份报告中，我们发现 Wingless (wg) 被需要来诱导蛹视网膜中先前未知的细胞死亡激增（“早期死亡”）。在这里，我们表明 wg 还需要在一个涉及 DIAP1 调节的过程中诱导更广泛研究的中蛹细胞死亡（“晚期死亡”）。此外，我们的数据表明 wg 在指定神经胶质样锥细胞方面具有以前未报道的作用。这种活性需要经典的 Wg 信号转导，并与 Notch 途径的活性相关。我们的工作拓宽了经典 Wg 信号转导的作用范围，包括新兴的果蝇视网膜中的多个模式形成步骤。
