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[大鼠束缚和冷应激后下丘脑含食欲素神经元的免疫反应性]

[Immunereactivity of hypothalamic orexin-containing neurons after restraint and cold stress in rats].

作者信息

Shainidze K Z, Novikova N S

出版信息

Ross Fiziol Zh Im I M Sechenova. 2009 Dec;95(12):1346-58.

Abstract

Studying of immunereactivity of orexin-containing neurons after restraint and cold stress has allowed to reveal a selective change of a degree ofimmunereactivity ofhypothalamic orexin-containing neurons. Orexin-containing neurons are located in structures 28, 29, 31 levels of brain slices and have the different degree of immunereactivity that indicates functional heterogeneity of a population of hypothalamic orexin-containing neurons. Structures and zones of hypothalamus involved in development of complex brain responses to restraint or cold stress applications were identified. Changes of immunereactivity of orexin-containing neurons located in the areas involved in system of regulation ofthermogenesis (DMH, PH and some zones LHA) suggest a possibility of orexin-containing neurons participation in thermoregulation.

摘要

对束缚和冷应激后含食欲素神经元的免疫反应性进行研究,已揭示出下丘脑含食欲素神经元免疫反应程度的选择性变化。含食欲素神经元位于脑切片的28、29、31层结构中,且具有不同程度的免疫反应性,这表明下丘脑含食欲素神经元群体存在功能异质性。已确定下丘脑参与对束缚或冷应激应用产生复杂脑反应的结构和区域。位于参与产热调节系统的区域(背内侧下丘脑、下丘脑后区和下丘脑外侧区的一些区域)的含食欲素神经元免疫反应性的变化表明,含食欲素神经元有可能参与体温调节。

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