Łabuz-Roszak Beata, Pierzhała Krystyna, Kumor Klaudiusz, Wyrozumska Katarzyna, Baran Anna, Werner Anna, Bak Ewa, Jaźwiecka Magdalena
Katedra i Klinika Neurologii, SP Szpital Kliniczny Nr 1 w Zabrzu, Slaski Uniwersytet Medyczny w Katowicach.
Wiad Lek. 2009;62(2):99-103.
Fatigue is a common symptom occuring in different neurological diseases. It has an influence on social and proffesional live, and daily living activities of the patients. The aim of the study was to assess frequency of fatigue and its association with depression and anxiety in patients with multiple sclerosis (MS).
The examined group consisted of 44 patients with MS (mean age: 36.3+/-9.4 years). The control group involved 30 healthy volunteers. All the subjects fulfilled two questionnaires: Fatigue Severity Scale and Hospital Anxiety and Depression Scale.
Fatigue was present in 29 MS patients (66%) and in 8 controls (26.7%) (p=0.0002). Anxiety was noticed in 11 MS patients (25%) and in 2 controls (6.7%) (p=0.002). Depression was diagnosed in 3 MS patients (6.8%) and 2 controls (6.7%) (NS). Frequency of fatigue was similar in women and men, but anxiety and depression were more common in women. There was no correlation between fatigue and age, duration of the disease and EDSS. An association between fatigue and depression, but not anxiety, was observed.
Fatigue is a very common symptom in MS, sometimes associated with depression. It should be considered in every patient with MS, independently from age, sex, disability and duration of the disease.
疲劳是不同神经系统疾病中常见的症状。它会影响患者的社交和职业生活以及日常生活活动。本研究的目的是评估多发性硬化症（MS）患者疲劳的发生率及其与抑郁和焦虑的关系。
被检查组由44例MS患者（平均年龄：36.3±9.4岁）组成。对照组包括30名健康志愿者。所有受试者均填写了两份问卷：疲劳严重程度量表和医院焦虑抑郁量表。
29例MS患者（66%）存在疲劳，8例对照组患者（26.7%）存在疲劳（p = 0.0002）。11例MS患者（25%）存在焦虑，2例对照组患者（6.7%）存在焦虑（p = 0.002）。3例MS患者（6.8%）被诊断为抑郁，2例对照组患者（6.7%）被诊断为抑郁（无显著性差异）。疲劳的发生率在女性和男性中相似，但焦虑和抑郁在女性中更为常见。疲劳与年龄、病程和扩展残疾状态量表（EDSS）之间无相关性。观察到疲劳与抑郁之间存在关联，但与焦虑无关。
疲劳是MS中非常常见的症状，有时与抑郁相关。对于每一位MS患者，无论其年龄、性别、残疾程度和病程如何，都应考虑到疲劳问题。
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