Department of Pediatrics, Division Neonatology, University of South Florida, College of Medicine, Tampa, FL 33612, USA.
J Cell Mol Med. 2010 Mar;14(3):488-95. doi: 10.1111/j.1582-4934.2010.01029.x. Epub 2010 Feb 5.
The timing of the umbilical cord clamping at birth is still controversial. In the modern era of medicine, the cord has been clamped early to facilitate resuscitation and stabilization of infants. However, recently delayed cord clamping has been supported by physicians because it allows for the physiological transfer of blood from the placenta to the infant. Many clinical studies have revealed that the delayed cord clamping elevates blood volume and haemoglobin and prevents anaemia in infants. Moreover, since it was known that umbilical cord blood contains various valuable stem cells such as haematopoietic stem cells, endothelial cell precursors, mesenchymal progenitors and multipotent/pluripotent lineage stem cells, the merit of delayed cord clamping has been magnified. In this review, we discuss the advantages and disadvantages of delayed cord clamping at birth. We highlight the importance of delayed cord clamping in realizing mankind's first stem cell transfer and propose that it should be encouraged in normal births.
脐带夹闭的时机在分娩时仍存在争议。在现代医学中，为了便于对婴儿进行复苏和稳定，脐带通常被早期夹闭。然而，最近有医生支持延迟夹闭脐带，因为这允许胎盘向婴儿进行生理性的血液转移。许多临床研究表明，延迟夹闭脐带可增加婴儿的血容量和血红蛋白，预防贫血。此外，由于众所周知脐带血中含有各种有价值的干细胞，如造血干细胞、内皮祖细胞、间充质祖细胞和多能/多谱系干细胞，因此延迟夹闭脐带的益处被放大了。在这篇综述中，我们讨论了延迟夹闭脐带的优缺点。我们强调了延迟夹闭脐带在实现人类首次干细胞转移中的重要性，并提出应鼓励在正常分娩中进行这种操作。
