Cao Ni-da, Zhao Ai-guang, Yang Jin-kun
The First Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Zhong Xi Yi Jie He Xue Bao. 2010 Feb;8(2):116-20. doi: 10.3736/jcim20100204.
Advanced gastric cancer has a low survival rate while traditional Chinese medicine (TCM) therapy has effects in inhibiting tumor growth, lengthening survival time and improving the quality of life.
To analyze the effects of integrated traditional Chinese and Western medicine therapy on the survival time and quality of life of advanced gastric cancer patients.
DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: A total of 95 advanced gastric cancer patients were enrolled and divided into comprehensive group (48 cases) and control group (47 cases). The patients in the comprehensive group from the First Department of Oncology, Longhua Hospital, were treated with TCM therapy and chemotherapy based on the gastric cancer treatment guidelines made by the First Department of Oncology of Longhua Hospital, and the patients in the control group from Renji Hospital and Ruijin Hospital in Shanghai were treated with chemotherapy only.
The survival time in the two groups were observed and compared. The Karnofsky score, body weight, the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) score, response rate and chemotherapy-related adverse events in the comprehensive group were observed.
The estimated median survival time in the comprehensive group was 16.12 months, longer than 9.64 months in the control group (P<0.05). The scores of function and symptom of EORTC QLQ-C30 in the comprehensive group decreased, while the overall health status increased, and the results indicated that the quality of life of the patients in the comprehensive group was improved. In the comprehensive group, the body weight after treatment was higher than that before treatment (P=0.037), while there was no difference in Karnofsky scores between that before and after treatment (P=0.061). All the patients in the comprehensive group were assessable. The complete response rate was 0, 3 cases had a partial response, 34 cases had stable disease, and 11 cases had disease progression. The overall response rate was 6.25% (3/48), and the disease control rate was 77.08% (37/48). No patient withdrew because of severe adverse events and there was no chemotherapy-related death.
Integrated traditional Chinese and Western medicine can prolong the survival time and improve the quality of life of advanced gastric cancer patients, and enhance the comprehensive effects.
晚期胃癌生存率低，而中医治疗在抑制肿瘤生长、延长生存时间及提高生活质量方面有一定作用。
分析中西医结合治疗对晚期胃癌患者生存时间及生活质量的影响。
设计、地点、参与者和干预措施：共纳入95例晚期胃癌患者，分为综合组（48例）和对照组（47例）。龙华医院肿瘤科一区的综合组患者依据龙华医院肿瘤科制定的胃癌治疗指南接受中医治疗及化疗，上海仁济医院和瑞金医院的对照组患者仅接受化疗。
观察并比较两组的生存时间。观察综合组的卡氏评分、体重、欧洲癌症研究与治疗组织核心生活质量问卷（EORTC QLQ-C30）评分、缓解率及化疗相关不良事件。
综合组估计中位生存时间为16.12个月，长于对照组的9.64个月（P<0.05）。综合组EORTC QLQ-C30的功能和症状评分降低，总体健康状况评分升高，结果表明综合组患者生活质量得到改善。综合组治疗后体重高于治疗前（P=0.037），治疗前后卡氏评分差异无统计学意义（P=0.061）。综合组所有患者均可评估。完全缓解率为0，3例部分缓解，34例病情稳定，11例病情进展。总缓解率为6.25%（3/48），疾病控制率为77.08%（37/48）。无患者因严重不良事件退出，无化疗相关死亡。
中西医结合可延长晚期胃癌患者生存时间，提高生活质量，增强综合疗效。
