Byts Nadiya, Sirén Anna-Leena
University of Würzburg, Department of Neurosurgery, Würzburg, Germany.
Exp Transl Stroke Med. 2009 Oct 21;1:4. doi: 10.1186/2040-7378-1-4.
The tissue protective functions of the hematopoietic growth factor erythropoietin (EPO) are independent of its action on erythropoiesis. EPO and its receptors (EPOR) are expressed in multiple brain cells during brain development and upregulated in the adult brain after injury. Peripherally administered EPO crosses the blood-brain barrier and activates in the brain anti-apoptotic, anti-oxidant and anti-inflammatory signaling in neurons, glial and cerebrovascular endothelial cells and stimulates angiogenesis and neurogenesis. These mechanisms underlie its potent tissue protective effects in experimental models of stroke, cerebral hemorrhage, traumatic brain injury, neuroinflammatory and neurodegenerative disease. The preclinical data in support of the use of EPO in brain disease have already been translated to first clinical pilot studies with encouraging results with the use of EPO as a neuroprotective agent.
造血生长因子促红细胞生成素（EPO）的组织保护功能与其对红细胞生成的作用无关。在脑发育过程中，EPO及其受体（EPOR）在多种脑细胞中表达，并在成年脑损伤后上调。外周给予的EPO可穿过血脑屏障，并在脑内激活神经元、神经胶质细胞和脑血管内皮细胞中的抗凋亡、抗氧化和抗炎信号，刺激血管生成和神经发生。这些机制是其在中风、脑出血、创伤性脑损伤、神经炎症和神经退行性疾病实验模型中发挥强大组织保护作用的基础。支持在脑部疾病中使用EPO的临床前数据已转化为首批临床试验研究，使用EPO作为神经保护剂取得了令人鼓舞的结果。
