激活而非抑制：针对酶原进行小分子干预 - Suppr

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超能文献

Activation instead of inhibition: targeting proenzymes for small-molecule intervention.

作者信息

Ottmann Christian, Hauske Patrick, Kaiser Markus

机构信息

Chemical Genomics Centre der Max-Planck-Gesellschaft, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany.

出版信息

Chembiochem. 2010 Mar 22;11(5):637-9. doi: 10.1002/cbic.201000024.

DOI:10.1002/cbic.201000024

PMID:20143368

Abstract

摘要

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Activation instead of inhibition: targeting proenzymes for small-molecule intervention.

作者信息

Ottmann Christian, Hauske Patrick, Kaiser Markus

机构信息

Chemical Genomics Centre der Max-Planck-Gesellschaft, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany.

出版信息

Chembiochem. 2010 Mar 22;11(5):637-9. doi: 10.1002/cbic.201000024.

DOI:10.1002/cbic.201000024

PMID:20143368

Abstract

摘要

相似文献

Activation instead of inhibition: targeting proenzymes for small-molecule intervention.

Chembiochem. 2010 Mar 22;11(5):637-9. doi: 10.1002/cbic.201000024.

Small molecules not direct activators of caspases.

Nat Chem Biol. 2007 Sep;3(9):519; author reply 520. doi: 10.1038/nchembio0907-519.

Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7.

Apoptosis. 2009 Oct;14(10):1135-44. doi: 10.1007/s10495-009-0388-9.

Crystal structure of the proenzyme domain of plasminogen.

Biochemistry. 1999 Aug 24;38(34):11180-8. doi: 10.1021/bi991130r.

Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.

Nat Chem Biol. 2006 Oct;2(10):543-50. doi: 10.1038/nchembio814. Epub 2006 Aug 27.

Small-molecule activators of a proenzyme.

Science. 2009 Nov 6;326(5954):853-8. doi: 10.1126/science.1177585.

Pepsinogen-like activation intermediate of plasmepsin II revealed by molecular dynamics analysis.

Proteins. 2008 Dec;73(4):814-27. doi: 10.1002/prot.22105.

Coumarin-derivative-based off-on catalytic chemodosimeter for Cu2+ ions.

Chem Commun (Camb). 2009 Aug 28(32):4838-40. doi: 10.1039/b908638b. Epub 2009 Jul 3.

Cathepsin D propeptide: mechanism and regulation of its interaction with the catalytic core.

Biochemistry. 2006 Dec 26;45(51):15474-82. doi: 10.1021/bi0614986.

Folding pathway mediated by an intramolecular chaperone: the structural and functional characterization of the aqualysin I propeptide.

J Mol Biol. 2001 Jan 5;305(1):151-65. doi: 10.1006/jmbi.2000.4233.

引用本文的文献

Hyperbaric oxygen therapy reduces apoptosis after spinal cord injury in rats.

Int J Clin Exp Med. 2014 Nov 15;7(11):4073-81. eCollection 2014.

Peptide-Modulated Activity Enhancement of Acidic Protease Cathepsin E at Neutral pH.

Int J Pept. 2012;2012:316432. doi: 10.1155/2012/316432. Epub 2012 Dec 17.

In Vitro Selection of Cathepsin E-Activity-Enhancing Peptide Aptamers at Neutral pH.

Int J Pept. 2011;2011:834525. doi: 10.1155/2011/834525. Epub 2011 Mar 22.