人类淋巴丝虫病中的淋巴管：寄生虫诱导的淋巴管重塑的体外模型
Lymphatics in human lymphatic filariasis: in vitro models of parasite-induced lymphatic remodeling.
作者信息
Bennuru Sasisekhar, Nutman Thomas B
机构信息
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0425, USA.
出版信息
Lymphat Res Biol. 2009 Dec;7(4):215-9. doi: 10.1089/lrb.2009.0022.
Abstract
Lymphatic filariasis characterized by the dysfunction of the lymphatics can lead to severe (and often) irreversible lymphedema and elephantiasis. Decades of research in the field shows that the establishment of the adult parasites in the lymphatics triggers a cascade of events that ultimately results in tissue scarring and fibrosis. In this minireview, we focus on the studies addressing the mechanisms underlying the parasite-induced lymphatic dilatation that suggests parasite-induced lymphatic remodeling and lymphangiogenesis may be the prelude towards developing chronic and irreversible filarial pathology.
摘要
以淋巴管功能障碍为特征的淋巴丝虫病可导致严重（且通常）不可逆的淋巴水肿和象皮肿。该领域数十年的研究表明，成年寄生虫在淋巴管中的定植引发了一系列事件，最终导致组织瘢痕形成和纤维化。在这篇迷你综述中，我们重点关注了有关寄生虫诱导淋巴管扩张潜在机制的研究，这些研究表明寄生虫诱导的淋巴管重塑和淋巴管生成可能是发展为慢性和不可逆丝虫病病理学的前奏。
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