Université Montpellier 1, Institut des Biomolécules Max Mousseron UMR CNRS 5247, Département Biopolymères Artificiels, Faculté de Pharmacie de Montpellier, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France.
Acta Biomater. 2010 Aug;6(8):3208-15. doi: 10.1016/j.actbio.2010.02.008. Epub 2010 Feb 6.
Sterile calcium hydrogenophosphate dihydrate (DCPD) (CaHPO(4).2H(2)O), calcium oxide and strontium carbonate powders were mixed in various liquid phases. Among these, ammonium phosphate buffer (0.75 M, pH 6.9) led to a novel strontium-containing calcium phosphate cement. At a 6/2.5/1.5 M ratio and for a liquid to powder ratio (L/P) of 0.5 mlg(-1), the initial paste was fluid and remained injectable for 12 min at 25 degrees C. It was easily obtained by mixing sterile powders and the liquid phase using the push-pull technique, avoiding complex mixing apparatus. The cement set after 15 min at 37 degrees C and was hard after 1h. The compressive strength was in the 20 MPa range, a value higher than that generally assigned to trabecular bone (5-15MPa). This strength appeared sufficient for repairing non-loading sites or reinforcing osteoporotic vertebrae (vertebroplasty). After setting, the initial mixture formed a strontium-calcium-deficient carbonate apatite. The radio-opacity of the resulting cement was three times greater than that of cortical bone because of the presence of strontium ions, a feature that complies with the requirements for vertebroplasty. Furthermore, the cement powder remained stable and retained its properties for at least 4 years.
无菌二水合磷酸氢钙（DCPD）（CaHPO(4).2H(2)O）、氧化钙和碳酸锶粉末被混合在各种液相中。其中，磷酸缓冲铵（0.75 M，pH 6.9）导致了一种新型的含锶的磷酸钙水泥。在 6/2.5/1.5 M 的比例和 0.5 mlg(-1) 的液固比下，初始糊剂是流体状的，在 25°C 下仍可注射 12 分钟。它可以通过使用推拉技术混合无菌粉末和液相来轻松获得，避免了复杂的混合设备。水泥在 37°C 下 15 分钟后凝固，1 小时后变硬。抗压强度在 20 MPa 范围内，高于一般赋予小梁骨的强度（5-15 MPa）。这个强度似乎足以修复非承重部位或增强骨质疏松的椎体（椎体成形术）。凝固后，初始混合物形成了一种锶钙缺乏的碳酸磷灰石。由于存在锶离子，所得水泥的射线不透性是皮质骨的三倍，这一特性符合椎体成形术的要求。此外，水泥粉末至少在 4 年内保持稳定并保持其性能。
