Chrcanovic Bruno Ramos, Reher Peter, Sousa Alexandre Andrade, Harris Malcolm
Oral Maxillofac Surg. 2010 Jun;14(2):81-95. doi: 10.1007/s10006-010-0205-1.
The aim of this paper is to explore the current theories about pretreatment assessment and dental management of patients receiving head and neck radiotherapy, and the therapeutic options to treat osteoradionecrosis of the jaws, based on the literature review.
Osteoradionecrosis is one of the most serious oral complications of head and neck cancer treatment. Osteoradionecrosis is a severe delayed radiation-induced injury, characterized by bone tissue necrosis and failure to heal. Osteoradionecrosis either stabilizes or gradually worsens and is notoriously difficult to manage. Because most cases occur in patients who were dentulous in the mandible at tumor onset, proper dental management is the single most important factor in prevention.
Complete dental clearance before treatment is no longer necessary. Controversy exists regarding the management of osteoradionecrosis of the maxillofacial skeleton because of the variability of this condition. The treatment of osteoradionecrosis has included local wound care, antibiotic therapy, surgical procedures, and the administration of hyperbaric oxygenation. Recently, new methods of treatment were introduced, according to the new theory about its pathophysiology.
本文旨在基于文献综述,探讨目前关于接受头颈部放疗患者的预处理评估和牙科管理的理论,以及治疗颌骨放射性骨坏死的治疗选择。
放射性骨坏死是头颈部癌症治疗最严重的口腔并发症之一。放射性骨坏死是一种严重的迟发性辐射诱导损伤,其特征为骨组织坏死且无法愈合。放射性骨坏死要么稳定,要么逐渐恶化,而且众所周知难以处理。由于大多数病例发生在肿瘤发病时下颌有牙的患者中,恰当的牙科管理是预防中唯一最重要的因素。
治疗前不再需要彻底清除牙齿。由于颌面部骨骼放射性骨坏死情况的变异性,其管理存在争议。放射性骨坏死的治疗包括局部伤口护理、抗生素治疗、外科手术以及高压氧治疗。最近,根据其病理生理学的新理论引入了新的治疗方法。