Department of Neurology, Division of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa.
Ann N Y Acad Sci. 2010 Jan;1184:154-72. doi: 10.1111/j.1749-6632.2009.05108.x.
Due to limitations posed by the restrictive blood-brain barrier, conventional drug delivery systems do not provide adequate cyto-architecture restoration and connection patterns that are essential for functional recovery in neurodegenerative disorders (NDs). Nanotechnology employs engineered materials or devices that interact with biological systems at a molecular level and could revolutionize the treatment of NDs by stimulating, responding to, and interacting with target sites to induce physiological responses while minimizing side effects. This review provides a concise discussion of the current applications of nano-enabled drug-delivery systems for the treatment of NDs, in particular Alzheimer's and Parkinson's diseases, and explores the future applications of nanotechnology in clinical neuroscience to develop innovative therapeutic modalities for the treatment of NDs.
由于血脑屏障的限制，传统的药物输送系统无法提供神经退行性疾病（NDs）中恢复功能所必需的细胞结构和连接模式。纳米技术采用工程材料或设备，在分子水平上与生物系统相互作用，通过刺激、响应和与靶标相互作用来诱导生理反应，同时最小化副作用，从而有可能彻底改变 NDs 的治疗方法。本文简要讨论了纳米药物输送系统在治疗 NDs（特别是阿尔茨海默病和帕金森病）方面的最新应用，并探讨了纳米技术在临床神经科学中的未来应用，以开发治疗 NDs 的创新治疗模式。
