Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Spine (Phila Pa 1976). 2010 Mar 1;35(5):511-6. doi: 10.1097/BRS.0b013e3181b52baf.
A comparative allometric study of body lengths in an animal model for human idiopathic-type scoliosis.
To compare body length variation among adult curved and noncurved curveback female guppies.
Tallness and/or abnormal anthropometric parameters have been correlated to idiopathic-type scoliosis (IS) in numerous studies. Heritable curvature in curveback has demonstrated morphologic and developmental similarities to human IS. Because control of body length in the guppy is heritable and variable, we investigated whether length might also be correlated to curvature in the curveback population.
Component body lengths were measured from digital photographs for 321 (246 curved and 75 noncurved) females. Sources of experimental variation were omitted by only measuring 2-dimensional curves in mature females all from the same pedigree, and raised under controlled conditions of diet and environment. Body length was divided into 2 component parts (precaudal and caudal). Body lengths were tested statistically for correlation to curvature and curve magnitude.
Although absolute length does not correlate to curvature, this survey of length in the curveback model reveals 2 important similarities to anthropometric studies of IS: that there are disproportionate body lengths among females with curvature, and the suggestion of an underlying growth abnormality among curved individuals.
In order to better characterize the relationship between growth, length disproportion, and curvature in the guppy, further studies are warranted. However, this inquiry further supports the usefulness of curveback as a model for understanding the basic biology of idiopathic-type scoliosis and encourages study of growth-related factors.
人类特发性脊柱侧凸动物模型的体长比较分析。
比较成年弯曲和非弯曲曲线背雌性孔雀鱼的体长变化。
在许多研究中，身高和/或异常人体测量参数与特发性脊柱侧凸（IS）相关。曲线背的遗传性弯曲在形态和发育上与人类 IS 相似。由于孔雀鱼的体长控制具有遗传性和可变性，我们研究了体长是否也与曲线背种群的弯曲相关。
从 321 只（246 只弯曲和 75 只非弯曲）雌性的数字照片中测量各部分身体长度。通过仅测量来自同一谱系的成熟雌性的二维曲线，并在饮食和环境条件受控的情况下饲养，避免了实验变异的来源。将体长分为两部分（前尾和尾）。对体长与弯曲和弯曲幅度进行了统计相关性测试。
尽管绝对长度与弯曲无关，但对曲线背模型中长度的调查揭示了与 IS 人体测量研究的两个重要相似之处：弯曲女性之间存在不成比例的身体长度，以及弯曲个体中存在潜在生长异常的暗示。
为了更好地描述孔雀鱼生长、长度不成比例和弯曲之间的关系，需要进一步的研究。然而，这项研究进一步支持了曲线背作为理解特发性脊柱侧凸基本生物学的模型的有用性，并鼓励对与生长相关的因素进行研究。
