接枝儿茶酚的聚乙二醇用于多种基质的聚乙二醇化。

Catechol-grafted poly(ethylene glycol) for PEGylation on versatile substrates.

机构信息

Department of Chemistry, Graduate School of Nanoscience & Nanotechonology, Molecular-level Interface Research Center, KAIST, Republic of Korea.

出版信息

Langmuir. 2010 Mar 16;26(6):3790-3. doi: 10.1021/la904909h.

DOI:10.1021/la904909h

PMID:20148541

Abstract

We report on catechol-grafted poly(ethylene) glycol (PEG-g-catechol) for the preparation of nonfouling surfaces on versatile substrates including adhesion-resistant PTFE. PEG-g-catechol was prepared by the step-growth polymerization of PEO to which dopamine, a mussel-derived adhesive molecule, was conjugated. The immersion of substrates into an aqueous solution of PEG-g-catechol resulted in robust PEGylation on versatile surfaces of noble metals, oxides, and synthetic polymers. Surface PEGylation was unambiguously confirmed by various surface analytical tools such as ellipsometry, goniometry, infrared spectroscopy, and X-ray photoelectron spectroscopy. Contrary to existing PEG derivatives that are difficult-to-modify synthetic polymer surfaces, PEG-g-catechol can be considered to be a new class of PEGs for the facile surface PEGylation of various types of surfaces.

摘要

我们报告了用于制备非粘性表面的儿茶酚接枝聚乙二醇（PEG-g-儿茶酚），其适用于多种基底，包括耐黏附的聚四氟乙烯（PTFE）。PEG-g-儿茶酚通过聚氧乙烯（PEO）的逐步聚合制备，其中多巴胺，一种贻贝类黏附分子，被连接到 PEO 上。将基底浸入 PEG-g-儿茶酚的水溶液中，会在贵金属、氧化物和合成聚合物的各种通用表面上产生稳定的聚乙二醇化。通过各种表面分析工具，如椭圆光度法、测角法、红外光谱法和 X 射线光电子能谱法，明确证实了表面聚乙二醇化。与现有的难以修饰的合成聚合物表面的 PEG 衍生物不同，PEG-g-儿茶酚可以被认为是一种新型的 PEG，用于各种类型表面的简便表面聚乙二醇化。