Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA.
Aging Male. 2010 Mar;13(1):1-9. doi: 10.3109/13685530903410625.
Prostate cancer (PCa) is the most common malignancy in men. Androgen deprivation therapy (ADT) is used in the treatment of locally advanced and metastatic PCa. Although its use has improved survival in a subset of patients, it also has negative consequences. Osteoporosis, sexual dysfunction, hot flashes and adverse changes in body composition are well-known and well-studied complications of ADT. Recent studies have also found metabolic complications in these men such as insulin resistance, diabetes and metabolic syndrome. In addition, these men might also experience higher cardiovascular mortality. Studies are needed to determine the mechanism behind these complications and to employ strategies to prevent them.
前列腺癌（PCa）是男性中最常见的恶性肿瘤。雄激素剥夺疗法（ADT）用于治疗局部晚期和转移性 PCa。尽管它的使用改善了一部分患者的生存，但也有负面后果。骨质疏松症、性功能障碍、热潮红和身体成分的不良变化是 ADT 的众所周知且研究充分的并发症。最近的研究还发现这些男性存在代谢并发症，如胰岛素抵抗、糖尿病和代谢综合征。此外，这些男性可能还会经历更高的心血管死亡率。需要研究来确定这些并发症的背后机制，并采取策略来预防它们。
