Department of Neurology, Academic Medical Centre, University of Amsterdam, the Netherlands.
J Thromb Haemost. 2010 May;8(5):877-83. doi: 10.1111/j.1538-7836.2010.03799.x. Epub 2010 Feb 9.
Cerebral venous and sinus thrombosis (CVT) is a rare form of thrombosis, with many different clinical manifestations. Better imaging techniques have greatly improved the diagnosis, but as a result of the paucity of controlled trials, choosing the optimal treatment for each patient often remains a challenge. Heparin is generally considered the mainstay of treatment, supported by data from a few small trials. More invasive treatment options are available, such as endovascular thrombolysis and--in more severe cases--decompressive hemicraniectomy. Furthermore, CVT is often accompanied by various neurological complications, such as seizures and intracranial hypertension, which require specific treatment. In this review we summarize the available treatment options for CVT and suggest which therapy should be reserved for which patients.
脑静脉和静脉窦血栓形成（CVT）是一种罕见的血栓形成形式，具有许多不同的临床表现。更好的成像技术极大地提高了诊断水平，但由于缺乏对照试验，为每个患者选择最佳治疗方案仍然是一个挑战。肝素通常被认为是治疗的基础，这一观点得到了一些小型试验的数据支持。更具侵袭性的治疗选择是可用的，如血管内溶栓，在更严重的情况下，减压性半脑切除术。此外，CVT 常伴有各种神经并发症，如癫痫发作和颅内压升高，这需要特定的治疗。在这篇综述中，我们总结了 CVT 的可用治疗选择，并提出了哪种治疗方法应该保留给哪些患者。
