Center for Plant Cell Biology, Institute for Integrative Genome Biology, Department of Botany and Plant Sciences, University of California at Riverside, Riverside, CA 92521, USA.
Plant J. 2010 May;62(3):518-28. doi: 10.1111/j.1365-313X.2010.04169.x. Epub 2010 Feb 9.
Arabidopsis thaliana EDM2 was previously shown to be specifically required for disease resistance mediated by the R protein RPP7. Here we provide additional data showing that the role of EDM2 in plant immunity is limited and does not include a function in basal defense. In addition, we found that EDM2 has a promoting effect on the floral transition. We further found that the protein kinase WNK8 physically interacts with EDM2 in the nucleus. Unlike EDM2, which serves as a substrate of this kinase, WNK8 appears not to be required for RPP7-mediated defense. As reported previously, however, WNK8 does affect flowering time. Epistasis analyses suggested that EDM2 acts upstream of the floral repressor FLC (AT5G10140) and downstream of WNK8 (AT5G41990) in a regulatory module that resembles the autonomous floral promotion pathway, comprising a set of mechanisms that are known to affect the floral transition by regulating FLC transcript levels.
拟南芥 EDM2 先前被证明是专门用于由 R 蛋白 RPP7 介导的抗病性。在这里，我们提供了额外的数据，表明 EDM2 在植物免疫中的作用是有限的，不包括在基础防御中的功能。此外，我们发现 EDM2 对花发育的转变有促进作用。我们进一步发现蛋白激酶 WNK8 在核内与 EDM2 发生物理相互作用。与作为该激酶底物的 EDM2 不同，WNK8 似乎不是 RPP7 介导的防御所必需的。然而，如前所述，WNK8 确实会影响开花时间。上位性分析表明，EDM2 在花抑制因子 FLC（AT5G10140）的上游和 WNK8（AT5G41990）的下游起作用，形成了一个类似于自主花发育促进途径的调控模块，包括一系列已知通过调节 FLC 转录水平来影响花发育转变的机制。
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