Cardiovascular Center, Far Eastern Memorial Hospital, Taipei, Taiwan.
Med Hypotheses. 2010 Jun;74(6):1026-9. doi: 10.1016/j.mehy.2010.01.004. Epub 2010 Feb 9.
Atrial fibrillation is the most common sustained cardiac arrhythmia. Obesity and metabolic syndrome are independent risk factors for atrial fibrillation, and epicardial adipose tissues are highly associated with the genesis of atrial fibrillation, compared to visceral fat. Adipocytes can produce inflammatory cytokines and adipocytokines, which may enhance inflammation and oxidative stress in patients with obesity or metabolic syndrome. Moreover, it is possible that local interactions between epicardial adipose tissue and the adjacent myocardium can directly produce electrical or structural remodelings in the atrium. Taken together, we hypothesized that epicardial adipocytes contain distinctive arrhythmogenicity through increases in inflammatory cytokines, adipocytokines, and adipocyte-cardiomyocyte interactions to induce atrial fibrillation.
心房颤动是最常见的持续性心律失常。肥胖和代谢综合征是心房颤动的独立危险因素，与内脏脂肪相比，心外膜脂肪组织与心房颤动的发生高度相关。脂肪细胞可以产生炎症细胞因子和脂肪细胞因子，这可能会加重肥胖或代谢综合征患者的炎症和氧化应激。此外，心外膜脂肪组织与相邻心肌之间的局部相互作用可能直接导致心房产生电或结构重塑。综上所述，我们假设心外膜脂肪细胞通过增加炎症细胞因子、脂肪细胞因子和脂肪细胞-心肌细胞相互作用而具有独特的致心律失常性，从而导致心房颤动。
